Frank Cackowski
Position Title
Assistant Professor - Clinical Scholar
Office Location
Karmanos Cancer Institute
Hudson-Webber Cancer Research Center - 715
4100 John R.
Detroit, MI 48201
Mailing Address
Karmanos Cancer Institute
4100 John R.
Mail Code: HW07AO
Detroit, MI 48201
Office Phone
313-576-8321
Education Training
(2003 - 2011) Doctor of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
(1999 - 2003) Bachelor of Science, Biological Science with University honors, Carnegie Mellon University, Pittsburgh, PA
Postgraduate Training
(2013 - 2017) Hematology/Oncology Fellow, University of Michigan Department of Internal Medicine, Division of Hematology/Oncology
(2011 - 2018) Physician Scientist Training Program, University of Michigan Department of Internal Medicine
(2011 - 2013) Internal Medicine Intern and Resident, University of Michigan Department of Internal Medicine, Ann Arbor, MI
Professional Experience
Faculty Appointments
(2020 - Present) Assistant Professor, Clinical Scholar, Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2017 - 2020) Clinical Lecturer, University of Michigan, Department of Internal Medicine, Division of Hematology/Oncology and Urology Oncology Clinic, Rogel Cancer Center, University of Michigan Hospital, Ann Arbor, MI
Board Certification
(2017 - Present) American Board of Medical Oncology
(2015 - Present) American Board of Internal Medicine
Honors and Awards
(2019) Department of Defense Congressionally Directed Medical Research Programs, Prostate Cancer Research Program Physician Research Award.
(2019) University of Michigan Rogel Cancer Center “Cells to Society” Lecture Series; Invited Lecture entitled “Cancer Dormancy”
(2018) Prostate Cancer Foundation Young Investigator Award
(2018) American Association for Cancer Research Dormancy and Minimal Residual Disease Meeting, Oral Presentation
(2017) University of Michigan Hem/Onc Fellowship Best Basic Science Paper
(2010) Bone Research Seminar, Invited Lecture and Award; Tokyo, Japan
(2009) American Society for Bone and Mineral Research Young Investigator Award and Oral Research Presentation
(2004) University of Pittsburgh, Department of Internal Medicine Research Day Poster Session First Prize
Publications
Peer-Reviewed Publications
Reports of Original Work
1. Cackowski, FC, Wang Y, Decker JT et al. “Detection and isolation of disseminated tumor cells in bone marrow of patients with clinically localized prostate cancer.” The Prostate. 2019; 79(14): 1715-27
2. Jung, Y., Cackowski, FC, Yumoto, K, Decker, AM, Wang, J, Kim, JK, Lee, E, Wang, Y, Chung, JS, Gursky, AM, Krebsbach, PH, Pienta, KJ, Morgan, TM, and RS Taichman. "CXCL12gamma Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes." Cancer Res. 2018; 78(8): 2026-2039.
Role: study conception and design
3. Lee, E., Wang, J., Jung, Y., Cackowski, FC, and RS Taichman. “Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancer.” J Cell Biochem. 2018; 119(4): 3697-705.
Role: study conception and design
4. Decker, AM, Jung Y, Cackowski, F.C., Yumoto K, Wang J, and RS Taichman. "Sympathetic Signaling Reactivates Quiescent Disseminated Prostate Cancer Cells in the Bone Marrow." Mol Cancer Res. 2017; 15(12): 1644-1655.
Role: study conception and design, and method development
5. Cackowski, FC, Eber, MR, Rhee, J, Decker, AM, Yumoto, K, Berry, JE, Lee, E, Shiozawa, Y, Jung, Y, Aguirre-Ghiso, JA, and RS Taichman. "Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy." J Cell Biochem. 2017; 118(4): 891-902.
6. Yumoto K, Eber MR, Wang J, Cackowski, FC, Decker AM, Lee E, Nobre, AR, Aguirre-Ghiso, JA, Jung, Y, and RS Taichman. “Axl is required for TGF-beta2-induced dormancy of prostate cancer cells in the bone marrow.” Sci Rep. 2016; 6:36520.
Role: Study conception and design, and method development
7. Shiozawa, Y, Berry, JE, Eber, MR, Jung, Y, Yumoto, K, Cackowski, FC, Yoon, HJ, Parsana, P, Mehra, R, Wang, J, McGee, S, Lee, E, Nagrath, S, Pienta, KJ, and RS Taichman. "The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer." Oncotarget. 2016; 7(27): 41217-32.
8. Jung, Y., Decker, AM, Wang, J, Lee, E, Kana, LA, Yumoto, K, Cackowski, FC, Rhee, J, Carmeliet, P, Buttitta, L, Morgan, TM and RS Taichman. "Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow." Oncotarget. 2016; 7(18): 25698-25711.
Role: performed experiments
9. Lee, E, Wang, J, Yumoto, K, Jung, Y, Cackowski, FC, Decker, AM, Li, Y, Franceschi, RT, Pienta, KJ, and RS Taichman. "DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis." Neoplasia. 2016; 18(9): 553-566.
Role: study conception and design
10. Cackowski, FC, Anderson, JL, Patrene, K, Choksi, RJ, Shapiro, SD, Windle, JJ, Blair, HC, and GD. Roodman. "Osteoclasts are important for bone angiogenesis." Blood. 2010; 115(1): 140-149.
11. Guo, P, Imanishi, Y, Cackowski, FC, Jarzynka, MJ, Tao, HQ, Nishikawa, R, Hirose, T, Hu, B, and SY Cheng. "Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma." Am J Pathol. 2005; 166(3): 877-890.
Role: performed experiments
12. Cackowski, FC, Xu, L, Hu, B and SY Cheng. "Identification of two novel alternatively spliced Neuropilin-1 isoforms." Genomics. 2004; 84(1): 82-94.
Review Articles
1. Lee CH, Decker AM, Cackowski, FC, and RS Taichman. "Bone microenvironment signaling of cancer stem cells as a therapeutic target in metastati prostate cancer." Cell Biol Toxicol. 2019; Jun 27 [Epub ahead of print] doi: 10.1007/s10565-019-09483-7
Role: writing
2. Cackowski, FC, and RS Taichman. "Minimal Residual Disease in Prostate Cancer." Adv Exp Med Biol. 2018; 1100: 47-53.
3. Cackowski, FC, and RS Taichman. "Parallels between hematopoietic stem cell and prostate cancer disseminated tumor cell regulation." Bone. 2019; 119: 82-6.
4. Decker AM, Cackowski FC., Jung Y, and RS Taichman. “Biochemical Changes in the Niche Following Tumor Cell Invasion.” J Cell Biochem. 2017; 118(8): 1956-1964
Role: writing
5. Decker, AM, Jung, Y, Cackowski, FC, and RS Taichman. "The role of hematopoietic stem cell niche in prostate cancer bone metastasis." J Bone Oncol. 2016; 5(3): 117-120.
Role: writing
Book Authorships, Editorships, and Chapters
1. Cackowski, FC, and T Else. “Adrenocortical Carcinoma.” In: Oncology Board Review, Second Edition: Frank Worden, Rami Khoriaty, Alex Pearson, and Erin Cobain, editors. Demos Medical; 2018
2. Cackowski, FC, T Else. “Pheochromocytoma and Paraganglioma.” In: Oncology Board Review, Second Edition: Frank Worden, Rami Khoriaty, Alex Pearson, and Erin Cobain, editors. Demos Medical; 2018.
PRESENTATIONS
Podium Presentations (refereed)
1. F.C. Cackowski, Y. Wang, J.T. Decker, K. Pienta, T.M. Morgan, and R.S. Taichman. Isolation and Analysis of Bone Marrow Disseminated Tumor Cells from Patients with Localized Prostate Cancer. American Association for Cancer Research Dormancy and Minimal Residual Disease Meeting. Montreal, QC, Canada: 2018. Oral presentation and Poster
2. F.C. Cackowski, J.L. Anderson, R. J. Choksi, K.D. Patrene, G.Q. Yao, K. Insogna, S.D. Shapiro, H.C. Blair, D.B. Stolz, J.J. Windle and G.D. Roodman. Osteoclasts Are Important for Bone Angiogenesis. American Society for Bone and Mineral Research, 31st Annual Meeting. Denver, CO; 2009. Oral presentation
Poster Presentations (refereed)
1. F.C. Cackowski, J.L. Anderson, R.J. Choksi, K.D. Patrene, F.P. Ross, D.B. Stolz, S.D. Shapiro, J.J. Windle, H.C. Blair and G.D. Roodman. PTHrP Stimulates Angiogenesis by Means of Osteoclast Derived MMP-9. IX International Meeting on Cancer Induced Bone Disease. Arlington, VA; 2009. Poster presentation
2. F. C. Cackowski, R.J. Choksi, J.J. Windle and G.D. Roodman. Angiogenic Potential of Osteoclasts. American Society for Bone and Mineral Research 30th Annual Meeting. Montreal, Quebec, Canada; 2008. Poster presentation
Other
1. Y. Wang, R.S. Taichman and F.C. Cackowski, (senior author). A New Immune Competent, Androgen Receptor Positive Mouse Model of Prostate Cancer Bone Metastasis. Prostate Cancer Foundation Research Retreat. Carlsbad, CA: 2019. Poster
2. F.C. Cackowski, Y. Wang. J.T. Decker, C. Sifuentes, S. Weindorf, K. A.M. Decker, Y. Jung, K. Yumoto, Y. Wang, L. Buttitta, N. Szerlip, Pienta, T. Morgan, and R.S. Taichman. Detection of Disseminated Tumor Cells from Patients with Localized Prostate Cancer. NCI Prostate Cancer SPORE Program Retreat. Ft. Lauderdale, FL: 2019. Poster.
3. F.C. Cackowski, Y. Wang, J.T. Decker, C. Sifuentes, S. Weindorf, K. Pienta, T. Morgan, and R.S. Taichman. Isolation and Analysis of Disseminated Tumor Cells from Patients with Localized Prostate Cancer. Prostate Cancer Foundation Research Retreat. Carlsbad, CA: 2018. Poster
4. F.C. Cackowski, Y. Wang, K. Pienta, T. Morgan, and R.S. Taichman. Analysis of Disseminated Tumor Cells from Patients with Localized Prostate Cancer. NCI Prostate Cancer SPORE Program Retreat. Ft. Lauderdale, FL: 2017. Poster
5. F.C. Cackowski, M. Eber, J. Rhee, A.M. Decker, K. Yumoto, J. Berry. E. Lee, Y. Shiozawa, J. Aguirre-Ghiso and R.S. Taichman. Mer Tyrosine Kinase Stimulates Disseminated Prostate Cancer Cellular Dormancy Escape. Prostate Cancer Foundation Scientific Retreat. Carlsbad, CA: 2016. Poster
6. F.C. Cackowski and R.S. Taichman. The Role of Mer Tyrosine Kinase in Prostate Cancer Cellular Dormancy. NIH/NCI Tumor Microenvironment Network Junior Investigator Meeting. Bethesda, MD: 2016. Oral presentation
7. F.C. Cackowski, M. Eber and R.S. Taichman. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cell Dormancy. NIH/NCI Tumor Microenvironment Network Junior Investigator Meeting. Los Angeles, CA: 2015. Oral presentation.