Michael Wilson
Position Title
Assistant Professor
Office Location
Karmanos Cancer Institute
Elliman Building, RM - 1248
421 E Canfield
Detroit, MI 48201
Mailing Address
Karmanos Cancer Institute
4100 John R., EL01MT
Detroit, MI 48201
Office Phone
313-578-4333
Education Training
Education
(2016) PhD, Wayne State University, Detroit, MI
(2011) BS, Grand Valley State University, Allendale, MI
Postgraduate Training
(2016 - 2022) Postdoctoral Fellowship, Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI
Professional Experience
Faculty Appointments
(2022 - Present) Assistant Professor, Department of Oncology, Wayne State University School of Medicine ,Detroit, MI
Major Professional Societies
(2021 - Present) Society for Reproductive Investigation
(2013 - Present) American Association for Cancer Research
(2010 - Present) American Society for Cell Biology
Research
Conduct basic and translational research as it relates to Gynecologic Oncology with a focus on endometrial cancer research in obesity and its contributions toward malignancy.
Publications
Original Observations
Wilson M.R., Harkins S., Reske J.J., Siwicki R.A., Adams M., Bae-Jump V.L., Teixeira J.M., Chandler R.L.. PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin. Reprod Biol Endocrinol. 21(1). 2023
Wilson M.R., Skalski H., Reske J.J., Wegener M., Adams M., Hostetter G., Hoffmann H.M., Bernard J.J., Bae‐Jump V.L., Teixeira J.M., Chandler R.L. Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner. Reprod Biol Endocrinol. 20(1):163. 2022
Reske JJ, Wilson MR, Armistead B, Harkins S, Perez C, Hit J, Adams M, Rothbart SB, Missmer SA, Fazleabas AT, Chandler RL. ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers. BMC Biol. 09/25/2022. PubMed PMID: 36153585.
Wilson MR, Reske JJ, Chandler RL. AP-1 Subunit JUNB Promotes Invasive Phenotypes in Endometriosis. Reprod Sci. 05/26/2022. PubMed PMID: 35616875.
Wilson MR, Reske JJ, Koeman J, Adams M, Joshi NR, Fazleabas AT, Chandler RL. SWI/SNF Antagonism of PRC2 Mediates Estrogen-Induced Progesterone Receptor Expression. Cells. 03/15/2022. PubMed PMID: 35326450.
Reske JJ, Wilson MR, Holladay J, Siwicki RA, Skalski H, Harkins S, Adams M, Risinger JI, Hostetter G, Lin K, Chandler RL. Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis. PLoS Genet. 12/17/2021;17(12):e1009986. PubMed PMID: 34941867.
Reske JJ, Wilson MR, Holladay J, Wegener M, Adams M, Chandler RL. SWI/SNF inactivation in the endometrial epithelium leads to loss of epithelial integrity. Hum Mol Genet. 12/18/2020;29(20):3412-3430. PubMed PMID: Hum Mol Genet.
Wilson MR, Reske JJ, Holladay J, Neupane S, Ngo J, Cuthrell N, Wegener M, Rhodes M, Adams M, Sheridan R, Hostetter G, Alotaibi FT, Yong PJ, Anglesio MS, Lessey BA, Leach RE, Teixeira JM, Missmer SA, Fazleabas AT, Chandler RL. ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Cell Rep. 11/10/2020;33(6):108366. PubMed PMID: 33176148.
Wilson MR, Holladay J, Sheridan R, Hostetter G, Berghuis B, Graveel C, Essenburg C, Peck A, Ho TH, Stanton M, Chandler RL. Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta. Stem Cell Res. 07/2020. PubMed PMID: 32464345.
Reske JJ, Wilson MR, Chandler RL. ATAC-seq normalization method can significantly affect differential accessibility analysis and interpretation. Epigenetics Chromatin. 04/22/2020;13(1):22. PubMed PMID: 32321567.
Wilson MR, Holladay J, Chandler RL. A mouse model of endometriosis mimicking the natural spread of invasive endometrium. Hum Reprod. 01/01/2020;35(1):58-69. PubMed PMID: 31886851.
Wilson MR, Reske JJ, Holladay J, Wilber GE, Rhodes M, Koeman J, Adams M, Johnson B, Su RW, Joshi NR, Patterson AL, Shen H, Leach RE, Teixeira JM, Fazleabas AT, Chandler RL. ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 08/07/2019;10(1):3554. PubMed PMID: 31391455.
Patki M, McFall T, Rosati R, Huang Y, Malysa A, Polin L, Fielder A, Wilson MR, Lonardo F, Back J, Li J, Matherly LH, Bepler G, Ratnam M. Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. Sci Rep. 10/30/2018;8(1):16006. PubMed PMID: 30375484.
Ravindran M, Wilson MR, Tong N, O'Connor C, Karim M, Polin L, Wallace-Povirk A, White K, Kushner J, Hou Z, Matherly LH, Gangjee A. Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem. 05/10/2018;61(9):4228-4248. PubMed PMID: 29701475.
Ravindra M, Wallace-Povirk A, Karim MA, Wilson MR, O'Connor C, White K, Kushner J, Polin L, George C, Hou Z, Matherly LH, Gangjee A. Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3- d]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. J Med Chem. 03/08/2018;61(5):2027-2040. PubMed PMID: 29425443.
Wilson MR, Hou Z, Wilson LJ, Ye J, Matherly LH. Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker. Biochem J. 10/15/2016;473(20):3545-3562. PubMed PMID: 27514717.
Golani LK, Wallace-Povirk A, Dies SM, Wong J, Ke J, Gu X, Raghavan S, Wilson MR, Li X, Polin L, de Waal PW, White K, Kushner J, O'Connor C, Hou Z, Xu HE, Melcher K, Dann CE 3rd, Matherly LH, Gangjee A. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. J Med Chem. 09/08/2016;59(17):7856-76. PubMed PMID: 27458733.
Wilson MR, Hou Z, Yang S, Polin L, Kushner J, White K, Huang J, Ratnam M, Gangjee A, Matherly LH. Targeting Nonsquamous Nonsmall Cell Lung Cancer via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates. Mol Pharmacol. 04/2016;89(4):425-34. PubMed PMID: 26837243.
Wang L, Wallace A, Raghavan S, Deis SM, Wilson MR, Yang S, Polin L, White K, Kushner J, Orr S, George C, O'Connor C, Hou Z, Mitchell-Ryan S, Dann CE 3rd, Matherly LH, Gangjee A. 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. J Med Chem. 09/10/2015;58(17):6938-59. PubMed PMID: 26317331.
Wilson MR, Kugel S, Huang J, Wilson LJ, Wloszczynski PA, Ye J, Matherly LH, Hou Z. Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. Biochem J. 07/01/2015;469(1):33-44. PubMed PMID: 25877470.
Golani LK, George C, Zhao S, Raghavan S, Orr S, Wallace A, Wilson MR, Hou Z, Matherly LH, Gangjee A. Structureactivity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter. J Med Chem. 10/09/2014;57(19):8152-66. PubMed PMID: 25234128.
Wilson MR, Hou Z, Matherly LH. Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter. J Biol Chem. 09/05/2014;289(36):25287-95. PubMed PMID: 25053408.