Position Title

Professor
Population Science

Office Location

Biostatistics Core
Mid-Med Lofts
87 E Canfield
Detroit, MI 48201

Mailing Address

Office Phone

(313) 576-8655

Office Fax

(313) 576-8656

Education Training

Education
(2006)  Ph.D. Biostatistics, University of Michigan, Ann Arbor, MI
(2002)  M.S. Biostatistics, University of Michigan, Ann Arbor, MI
(2000)  M.S. Statistics, University of Toledo, Toledo, OH
(1993)  B.S. Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China

Professional Experience

Faculty Appointments
(2022 - Present) Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2014 - 2022) Associate Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2006 - 2014) Assistant Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, MI

Major Professional Societies

(2001-Present)  American Statistical Association (ASA)
(2008)  American Association for Cancer Research (AACR)
(2007)  Institute of Mathematical Statistics (IMS)
(2005)  International Biometric Society/Eastern North Americal Region (IBS)

Honors and Awards

(2015)  Wayne State University School of Medicine College Teaching Award
(2011)  Wayne State University School of Medicine College Teaching Award
(2008)  AACR travel award to the 1st Caner Biostatistics Workshop
(2007)  IMS tracel award to the 10th Meeting of New Researchers in Statistics and Probability

Courses taught

FPH 7350: Statistical Programming - Public Health Practice
FPH 7990: Directed Study - Community Health

Research Interests

Dr. Chen specializes in the design and statistical analyses of research projects in the basic science and clinical programs of the Department of Oncology, as well as for researchers across the School of Medicine who are members of the Karmanos Cancer Institute. She functions as the primary statistical collaborator on research projects directed by investigators from the (former) Molecular Biology and Genetics Program, the Population Studies and Prevention Program, and the Molecular Imaging and Diagnostics Program. Her research interests include adaptive clinical trial design, biomarker discovery, high dimensional genomic or proteomic data mining, pharmacogenomic modeling, and Bayesian statistics.  Dr. Chen also served as referee for journals such as Biometrics, Journal of Clinical Oncology, Statistics in Medicine, and Journal of Probability and Statistics.

Publications

1. Nakajima K, Kho DH, Yanagawa T, Harazono Y, HoganV, Chen W, Rouba A, Mehra R, Raz A Galectin-3 cleavage alters bone remodeling: Different outcomes in breast and prostate cancer skeletal metastasis. Cancer Research 2016 Feb PMID:26837763

2. Fountain MD, Abernathy LM, Lonardo F, Rothstein SE, Dominello MM, Chen W, Gadgeel SM, Joiner MC, Hillman GG. Radiation-Induced Esophagitis is Mitigated by Soy Isoflavones. Frontiers in Oncology. 2015 Oct 21; DOI:10.3389/fonc.2015.00238 PubMed PMID: 26557504

3. Soubani AO, Chen W, Jang H. The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus. Heart Lung. 2015 Sep-Oct;44(5):441-7. doi: 10.1016/j.hrtlng.2015.06.007. Epub 2015 Jul 23. PMID:26212460

4. Ahmad A, Ginnebaugh KR, Sethi S, Chen W, Ali R, Mittal S, Sarkar FH. miR-20b is up-regulated in brain metastases from primary breast cancers. Oncotarget. 2015; 6(14):12188-95. PMID: 25893380.

5. Wang G, Niu X, Zhang W, Caldwell JT, Edwards H, Chen W, Taub JW, Zhao L, Ge Y. Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer. Cancer Lett. 2015 Jan 28;356(2 Pt B):656-68.
doi: 10.1016/j.canlet.2014.10.015. PMID: 25458954.

6. Meng F, Speyer CL, Zhang B, Zhao Y, Chen W, Gorski DH, Miller FR, Wu G. PDGFRα and β Play Critical Roles in Mediating Foxq1-Driven Breast Cancer Stemness and Chemoresistance. Cancer Res. 2015; 75(3):584-9. DOI: 10.1158/0008-5472.CAN-13-3029 PMID 25502837

7. Bollig-Fischer A, Chen W, Gadgeel SM, Wenzlaff AS, Cote ML, Schwartz AG, Bepler G. Racial diversity of actionable mutations in non-small cell lung cancer. Journal of Thoracic Oncology. 2015; 10(2):250-5. PMID: 25376516.

8. Lin HS, Rowley JA, Folbe AJ, Yoo GH, Badr MS, Chen W. Transoral Robotic Surgery for Treatment of Obstructive Sleep Apnea: Factors Predicting Surgical Response. The Laryngoscope. 2015; 125(4):1013-20 doi: 10.1002/lary.24970 PMID: 25346038

9. Kong D, Sethi S, Li Y, Chen W, Sakr WA, Heath E, Sarkar FH. Androgen Receptor Splice Variants Contribute to Prostate Cancer Aggressiveness through Induction of EMT and the Expression of Stem Cell Marker Genes. The Prostate. 2015; 75(2):161-74 doi: 10.1002/pros.22901 PMID: 25307492

Faculty Status

Population Science

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