Jing Li
Position Title
Professor
Basic Science
Office Location
Karmanos Cancer Institute4100 John R.
Hudson-Webber Cancer Research Center, Room 523
Mail Code: HW04HO
Detroit, MI 48201
Office Phone
313-576-8258Education Training
Education
(2000–2003) Ph.D. Pharmacology, National University of Singapore, Singapore
(1994–1997) M.S. Pharmaceutical Science, West China University of Medical Sciences, Chengdu, China
(1989–1994) B.S. Clinical Pharmacy, West China University of Medical Sciences, Chengdu, China
Postgraduate Training
(2003–2006) Postdoctoral Fellowship, Clinical Pharmacology and Drug Development, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
Professional Experience
Faculty Appointments
(2014–Present) Associate Professor (tenured), Department of Oncology. Wayne State University School of Medicine, Detroit, MI
(2010–Present) Adjunct Assistant Professor, Department of Pharmaceutical Sciences, Wayne State University School of Pharmacy, Detroit, MI
(2011–2014) Assistant Professor, Department of Oncology. Wayne State University School of Medicine, Detroit, MI
(2006–2012) Assistant Professor, Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI
(1997–1999) Instructor, Department of Pharmacology, Fudan University School of Pharmacy, Shanghai, China
Hospital or Other Professional Appointments
(2006–Present) Director of Pharmacology Core, Karmanos Cancer Institute, Detroit, MI
Major Professional Societies
American Society of Clinical Pharmacology and Therapeutics
American Society of Clinical Oncology
American Association of Cancer Research
American Association of Pharmaceutical Sciences
Honors and Awards
(2014) Simcyp Academic Award (first-place) in recognition of scientific research which is leading the field of IVIVE, ADME, pharmaceutics, and modeling and simulation
(2006) Presidential Trainee Award, American Society of Clinical Pharmacology and Therapeutics (ASCPT)
Courses taught
CB 7240: Principles of Cancer Therapy
CB 7990: Research Technologies in Cancer Research
PSC 3310: Principles of Drug Disposition
PSC 7040: Advanced Drug Formulation and Delivery I
Research Interests
Clinical Pharmacology of anticancer drugs
Quantitative pharmacology: population (nonlinear mixed effects) pharmacokinetic pharmacodynamic modeling; physiologically-based pharmacokinetic modeling
Pharmacometabolomics
Publications
Hege Hurrish K, Qiao X, Li X, Su Y, Carter J, Ma J, Kalpage HA, Hüttemann M, Edwards H, Wang G, Kim S, Dombkowski A, Bao X, Li J, Taub JW, Ge Y. Co-targeting of HDAC, PI3K, and Bcl-2 results in metabolic and transcriptional reprogramming and decreased mitochondrial function in acute myeloid leukemia.. Biochemical pharmacology. 11/01/2022;205:115283. PubMed PMID: 36208684.
Yue Y, Bao X, Jiang J, Li J. Evaluation and correction of injection order effects in LC-MS/MS based targeted metabolomics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 10/19/2022;1212:123513. PubMed PMID: 36283260.
Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, Li J, Ye H, Boyd K, Huang RR, Dodson J, Boutros P, Bindra RS, Shuch B. Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.. Oncotarget. 09/14/2022;13:1054-1067. PubMed PMID: 36128328.
Jiang J, Bao X, Yue Y, Schiff D, Bindra R, Li J. Development and validation of a liquid chromatography coupled with tandem mass spectrometry method for determining total and unbound pamiparib in human plasma and brain tumors. Biomedical chromatography : BMC. 08/08/2022:e5478. PubMed PMID: 35938683.
Lee R, Li J, Li J, Wu CJ, Jiang S, Hsu WH, Chakravarti D, Chen P, LaBella KA, Li J, Spring DJ, Zhao D, Wang YA, DePinho RA. Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.. Cancer discovery. 07/06/2022;12(7):1702-1717. PubMed PMID: 35537038.
Li J, Jiang J, Bao X, Kumar V, Alley SC, Peterson S, Lee AJ. Mechanistic Modeling of Central Nervous System Pharmacokinetics and Target Engagement of HER2 Tyrosine Kinase Inhibitors to Inform Treatment of Breast Cancer Brain Metastases.. Clinical cancer research : an official journal of the American Association for Cancer Research. 06/21/2022:OF1-OF13. PubMed PMID: 35727144.
Udumula MP, Sakr S, Dar S, Alvero AB, Ali-Fehmi R, Abdulfatah E, Li J, Jiang J, Tang A, Buekers T, Morris R, Munkarah A, Giri S, Rattan R. Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism.. Molecular metabolism. 11/01/2021;53:101272. PubMed PMID: 34144215.
Bellail AC, Jin HR, Lo HY, Jung SH, Hamdouchi C, Kim D, Higgins RK, Blanck M, le Sage C, Cross BCS, Li J, Mosley AL, Wijeratne AB, Jiang W, Ghosh M, Zhao YQ, Hauck PM, Shekhar A, Hao C. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors.. Science translational medicine. 10/13/2021;13(615):eabh1486. PubMed PMID: 34644148.
Mehta S, Fiorelli R, Bao X, Pennington-Krygier C, Derogatis A, Kim S, Yoo W, Li J, Sanai N. A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma.. Clinical cancer research. 10/2021:CCR-21-1096. Epub 2021 Oct 26. PubMed PMID: 34702773. doi: 10.1158/1078-0432.
Bao X, Wu J, Jiang J, Tien AC, Sanai N, Li J. Quantitative protein expression of blood-brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer.. Clinical and translational science. 07/01/2021;14(4):1265-1271. PubMed PMID: 33566445.
Qiao X, Ma J, Knight T, Su Y, Edwards H, Polin L, Li J, Kushner J, Dzinic SH, White K, Wang J, Lin H, Wang Y, Wang L, Wang G, Taub JW, Ge Y. The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.. Blood cancer journal. 06/07/2021;11(6):111. PubMed PMID: 34099621.
Wallace-Povirk A, Tong N, Wong-Roushar J, O'Connor C, Zhou X, Hou Z, Bao X, Garcia GE, Li J, Kim S, Dann CE 3rd, Matherly LH, Gangjee A. Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-iminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.. Bioorganic & medicinal chemistry. 05/01/2021;37:116093. PubMed PMID: 33773393.
Li J, Jiang J, Wu J, Bao X, Sanai N. Physiologically Based Pharmacokinetic Modeling of Central Nervous System Pharmacokinetics of CDK4/6 Inhibitors to Guide Selection of Drug and Dosing Regimen for Brain Cancer Treatment.. Clinical pharmacology and therapeutics. 02/01/2021;109(2):494-506. PubMed PMID: 32799335.
Austin CA, Inutan ED, Bohrer BC, Li J, Fischer JL, Wijerathne K, Foley CD, Lietz CB, Woodall DW, Imperial LF, Clemmer DE, Trimpin S, Larsen BS. Resolving Isomers of Star-Branched Poly(Ethylene Glycols) by IMS-MS Using Multiply Charged Ions.. Journal of the American Society for Mass Spectrometry. 01/06/2021;32(1):21-32. PubMed PMID: 32510213.
Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Oncometabolites suppress DNA repair by disrupting local chromatin signaling.. Nature. 06/01/2020;582(7813):586-591. PubMed PMID: 32494005.
Bao X, Wu J, Xie Y, Kim S, Michelhaugh S, Jiang J, Mittal S, Sanai N, Li J. Protein Expression and Functional Relevance of Efflux and Uptake Drug Transporters at the Blood-Brain Barrier of Human Brain and Glioblastoma.. Clinical pharmacology and therapeutics. 05/01/2020;107(5):1116-1127. PubMed PMID: 31664714.
Mpilla G, Aboukameel A, Muqbil I, Kim S, Beydoun R, Philip PA, Mohammad RM, Kamgar M, Shidham V, Senapedis W, Baloglu E, Li J, Dyson G, Xue Y, El-Rayes B, Azmi AS. PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors.. Cancers. 1/29/2019;11(12). PubMed PMID: 31795447.
Zhou Q, Pan H, Li J. Molecular Insights into Potential contributions of Natural Polyphenols to Lung Cancer Treatment. Cancers. 10/15/2019;11(10). PubMed PMID: 31618955.
Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE 3rd, Gangjee A, Matherly LH. Novel Pyrrolo[3,2- d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.. Molecular cancer therapeutics. 10/01/2019;18(10):1787-1799. PubMed PMID: 31289137.
Tien AC, Li J, Bao X, Derogatis A, Kim S, Mehta S, Sanai N. A Phase 0 Trial of Ribociclib in Recurrent Glioblastoma Patients Incorporating a Tumor Pharmacodynamic- and Pharmacokinetic-Guided Expansion Cohort.. Clinical cancer research. 10/01/2019;25(19):5777-5786. PubMed PMID: 31285369.
Moriyama T, Liu S, Li J, Meyer J, Zhao X, Yang W, Shao Y, Heath R, Hnízda A, Carroll WL, Yang JJ. Mechanisms of NT5C2-Mediated Thiopurine Resistance in Acute Lymphoblastic Leukemia.. Molecular cancer therapeutics. 10/01/2019;18(10):1887-1895. PubMed PMID: 31358663.
Miller TW, Traphagen NA, Li J, Lewis LD, Lopes B, Asthagiri A, Loomba J, De Jong J, Schiff D, Patel SH, Purow BW, Fadul CE. Tumor pharmacokinetics and pharmacodynamics of the CDK4/6 inhibitor ribociclib in patients with recurrent glioblastoma.. Journal of neuro-oncology. 09/01/2019;144(3):563-572. PubMed PMID: 31399936.
Bao X, Wu J, Shuch B, LoRusso P, Bindra RS, Li J. Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry. Scientific reports. 08/02/2019;9(1):11238. PubMed PMID: 31375752.
Bao X, Wu J, Sanai N, Li J. Determination of total and unbound ribociclib in human plasma and brain tumor tissues using liquid chromatography coupled with tandem mass spectrometry.. Journal of pharmaceutical and biomedical analysis. 03/20/2019;166:197-204. PubMed PMID: 30660034.
Bao X, Wu J, Kim S, LoRusso P, Li J. Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients.. Journal of clinical pharmacology. 01/01/2019;59(1):20-34. PubMed PMID: 30052267.
Rosati R, Polin L, Ducker C, Li J, Bao X, Selvakumar D, Kim S, Xhabija B, Larsen M, McFall T, Huang Y, Kidder BL, Fribley A, Saxton J, Kakuta H, Shaw P, Ratnam M. Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer.. Clinical cancer research : an official journal of the American Association for Cancer Research. 12/15/2018;24(24):6509-6522. PubMed PMID: 30185422.
Saadat N, Liu F, Haynes B, Nangia-Makker P, Bao X, Li J, Polin LA, Gupta S, Mao G, Shekhar MP. Nano-delivery of RAD6/Translesion Synthesis Inhibitor SMI#9 for Triple-negative Breast Cancer Therapy.. Molecular cancer therapeutics. 12/01/2018;17(12):2586-2597. PubMed PMID: 30242094.
Patki M, McFall T, Rosati R, Huang Y, Malysa A, Polin L, Fielder A, Wilson MR, Lonardo F, Back J, Li J, Matherly LH, Bepler G, Ratnam M. Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor.. Scientific reports. 10/30/2018;8(1):16006. PubMed PMID: 30375484.
McHugh CI, Thipparthi MR, Lawhorn-Crews JM, Polin L, Gadgeel S, Akoury J, Mangner TJ, Douglas KA, Li J, Ratnam M, Shields AF. Using Radiolabeled 3'-Deoxy-3'-18F-Fluorothymidine with PET to Monitor the Effect of Dexamethasone on Non-Small Cell Lung Cancer.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 10/01/2018;59(10):1544-1550. PubMed PMID: 29674424.
Sanai N, Li J, Boerner J, Stark K, Wu J, Kim S, Derogatis A, Mehta S, Dhruv HD, Heilbrun LK, Berens ME, LoRusso PM. Phase 0 Trial of AZD1775 in First-Recurrence Glioblastoma Patients.. Clinical cancer research : an official journal of the American Association for Cancer Research. 08/15/2018;24(16):3820-3828. PubMed PMID: 29798906.
Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM. Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair.. Nature genetics. 08/01/2018;50(8):1086-1092. PubMed PMID: 30013182.
Thakur MK, Heilbrun L, Dobson K, Boerner J, Stark K, Li J, Smith D, Heath E, Fontana J, Vaishampayan U. Phase I Trial of the Combination of Docetaxel, Prednisone, and Pasireotide in Metastatic Castrate-Resistant Prostate Cancer.. Clinical genitourinary cancer. 06/01/2018;16(3):e695-e703. PubMed PMID: 29534939.
Bao X, Wu J, Sanai N, Li J. A liquid chromatography with tandem mass spectrometry method for quantitating total and unbound ceritinib in patient plasma and brain tumor.. Journal of pharmaceutical analysis. 02/01/2018;8(1):20-26. PubMed
PMID: 29568664.
Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang J, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R. Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice.. Gastroenterology. 01/01/2018;154(1):224-237. PubMed PMID: 28923496.
Complete List of Publications in MyBibliography:
https://www.ncbi.nlm.nih.gov/sites/myncbi/1JCXa3CUJiCAB/bibliography/47188821/public/?sort=date&direction=ascending
Link to the Pharmacology Core:
https://www.karmanos.org/pharm