Lois Ayash
Position Title
Professor - ClinicalHematology-Oncology
Office Location
Karmanos Cancer Institute4100 John R.
Hudson-Webber Cancer Research Center, 4th Floor
Mail Code: HW04HO
Detroit, MI 48201
Office Phone
(313) 576-8711Education Training
Education
(1981) M.D.: University of Massachusetts Medical School, Worcester, MA
(1986) B.S. Biology (summa cum laude): Southeastern Massachusetts University, No. Dartmouth, MA
Postgraduate Training
(1988-1990) Research Fellow in Bone Marrow Transplantation, Dana-Farber Cancer Institute, Boston, MA
(1985-1988) Clinical Fellow in Hematology/Oncology, SUNY Health Science Center, Syracuse, NY
(1981-1984) Internal Medicine Residency, St. Vincent Hospital, Worcester, MA
Professional Experience
Faculty Appointments
(2010-Present) Professor of Medicine, Department of Oncology, Barbara Ann Karmanos Cancer Institute/Center and Wayne State University, Detroit, MI
(2005-2010) Professor of Medicine, Department of Internal Medicine, Wayne State University, Detroit, MI
(2005) Clinical Associate Professor, Wayne State University, Detroit, MI
(1997-2004) Clinical Associate Professor of Medicine, University of Michigan Medical School
(1994-1996) Assistant Professor Instructor in Medicine, Harvard Medical School in Medicine, Cambridge, MA
(1990-1994) Instructor, Harvard Medical School
(1989-1990) Research Fellow in Medicine, Harvard Medical School, Cambridge, MA
(1988-1989) Clinical Fellow in Medicine, Harvard Medical School, Cambridge, MA
Hospital or Other Professional Appointments
(2009-Present) Chairperson, Data Safety and Monitoring Committee, Karmanos Cancer Institute, Detroit, MI
(2005-Present) Professor of Medicine, Barbara Ann Karmanos Cancer Institute/Center at Wayne State University, Detroit, MI
(2005-2009) Data Safety and Monitoring Committee Member, Karmanos Cancer Institute, Detroit, MI
(2005) Associate Professor of Medicine, Karmanos Cancer Institute, Wayne State University, Detroit, MI
(2001-2004) Institutional Review Board, University of Michigan Medical Center, Ann Arbor, MI
(1997-2004) Clinical Associate Professor of Medicine, University of Michigan Medical Center, Ann Arbor, MI
(1997-2001) Protocol Review Committee, University of Michigan Medical Center, Ann Arbor, MI
(1994-1996) Assistant Professor in Medicine, Dana-Farber Cancer Institute, Boston, MA
(1993-1995) Co-Director, Solid Tumor Autologous Marrow Program, Dana-Farber Cancer Institute, Boston, MA
(1990-1994) Instructor in Medicine, Solid Tumor Autologous Marrow Program, Dana-Farber Cancer Institute, Boston, MA
(1989-1996) Associate in Medicine, Solid Tumor Autologous Marrow Program, the Beth Israel Hospital, Boston, MA
Major Professional Societies
(2002-Present) – American Society of Hematology, Member
(1997-Present) – Central Society for Clinical Research, Member
(1997-Present) – Bone Marrow & Stem Cell Transplant Committee, SWOG, Member
(1995) – Working Committee, North American Bone Marrow Transplant Registry, Breast and Solid Tumor Committee, Working Committee
(1994) – Working Committee, Blood Stem Cell Transplantation Consensus Meeting, Heemskerk, The Netherlands, Working Committee
(1992-1996) – Cancer & Leukemia Group B, No. 3330, Investigator
(1989) – American Society of Clinical Oncology
(1989) – Massachusetts Medical Society
Board Certification
(1987) Subspecialty Certification in Medical Oncology, American Board of Internal Medicine
(1984) Diplomate, American Board of Internal Medicine
Honors and Awards
(2008, 1994) School of Medicine Teaching Award, Wayne State University School of Medicine
(1994) Presenter, American Cancer Society Science Writer Seminar
(1991-1994) American Cancer Society Career Development Award
(1985-1986) American Cancer Society Clinical Fellowship in Oncology
Courses taught
Medical Resident Instruction
Research Interests
Clinical trials in autologous and allogeneic hematopoietic stem cell transplant for hematologic and solid tumor malignancies, with a special interest in testicular carcinomas.
Publications
1. Ayash L, Hunt M, Antman K, Nadler L, Wheeler C, Takvorian T, Elias A, Antin JH, Greenough T, Eder J: Hepatic veno-occlusive disease in autologous bone marrow transplantation of solid tumors and lymphomas. J Clin Oncol 8:1699-1706, 1990.
2. Ayash LJ, Wright JE, Tretyakov O, Gonin R, Elias A, Wheeler C, Rosovsky A, Antman K, Frei E: Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response. J Clin Oncol 10:995-1000, 1992.
3. Ayash L, Elias A, Wheeler C, Reich E, Schwartz G, Mazanet R, Tepler I, Warren D, Lynch C, R Gonin, Schnipper L, Frei E, Antman K: Double dose-intensive chemotherapy with autologous marrow and peripheral blood progenitor cell support for metastatic breast cancer: a feasibility study. J Clin Oncol 12:37-44, 1994.
4. Ayash LJ, Elias A, Hunt M, Demetri G, Wheeler C, Tepler I, Schwartz G, Mazanet R, Reich E, McCauley M, Antman K, Anderson KC: Recombinant human erythropoietin for the treatment of the anemia associated with autologous bone marrow transplantation. Br J Haematol 87:153-161, 1994.
5. Wright JE, Elias A, Tretyakov O, Holden S, Anderson J, Wheeler C, Schwartz G, Tepler I, Rosowsky A, Frei E III, Ayash LJ: High-dose ifosfamide, carboplatin, and etoposide pharmacokinetics: correlation of plasma blood levels with renal toxicity. Cancer Chemother Pharmacol 36:345-351, 1995
6. Ayash LJ, Wheeler C, Fairclough D, Schwartz G, Reich E, Warren D, Schnipper L, Antman K, Frei E III, Elias A: Prognostic factors for prolonged progression-free survival with high-dose chemotherapy with autologous stem cell support for advanced breast cancer. J Clin Oncol 13:2043-2049, 1995.
7. Ayash L, Elias A, Schwartz G, Wheeler C, Ibrahim J, Teicher B, Reich E, Warren D, Lynch C, Richardson P, Schnipper L, Frei E, Antman K: Double dose-intensive chemotherapy with autologous stem cell support for metastatic breast cancer: No improvement in progression-Free survival by the sequence of high-dose melphalan followed by CTCb. J Clin Oncol 14:2984-2992, 1996.
8. Ayash L, Elias A, Ibrahim J, Schwartz G, Wheeler C, Reich E, Lynch C, Warren D, Shapiro C, Richardson P, Hurd D, Schnipper L, Frei E, Antman K: High-dose multimodality therapy with autologous stem cell support for stage III breast cancer. J Clin Oncol 1998; 16:1000-1007.
9. Ayash LJ, Clarke M, Silver SM, Braun T, Uberti J, Ratanatharathorn V, Reynolds C, Ferrara J, Broun ER, Adams PT. Double dose-intensive chemotherapy with autologous stem cell support for relapsed and refractory testicular cancer: The University of Michigan experience and literature review. Bone Marrow Transplant 2001; 27:939-947.
10. Ayash LJ, Ratanatharathorn V, Braun T, Silver SM, Reynolds CM, Uberti JP. Unrelated donor bone marrow transplantation using a chemotherapy-only preparative regimen for adults with high-risk acute myelogenous leukemia. Am J Hemotol 2007 Jan:82(1):6-14.