Zeng-Quan Yang
Position Title
Professor
Basic Science
Office Location
Karmanos Cancer Institute4100 John R.
Mail Code: HW08AO
Detroit, MI 48201
Office Phone
(313)-576-8339Office Fax
(313)-576-8029Education Training
Education
(1996-2001) Ph.D. Medical Science, Tokyo Medical and Dental University, Tokyo, Japan
(1987-1990) M.S Basic Medical Science, Peking Union Medical College (Chinese Academy of Medical Sciences), Beijing, China
(1980-1985) B.S. Medicine, Taishan Medical College, Shandong, China
Postgraduate Training
(2001-2004) Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan Medical School and Comprehensive Cancer Center, Ann Arbor, MI
Professional Experience
Faculty Appointments
(2022 - Present) Professor, Department of Oncology, Wayne State University, Detroit, MI
(2014 - 2022) Associate Professor, Department of Oncology, Wayne State University, Detroit, MI
(2008 - 2014) Assistant Professor, Department of Oncology, Wayne State University, Detroit, MI
(2004 - 2008) Research Assistant Professor, Karmanos Cancer Institute, Wayne State University, Detroit, MI
Hospital and Other Professional Appointments
(2004 - Present) Member, Karmanos Cancer Institute, Detroit, MI
(2004 - 2008) Research Assistant Professor, Karmanos Cancer Institute, Wayne State University, Detroit, MI
(1992 - 1996) Senior Research Investigator, Department of Cytogenetics, National Institute for Family Planning, Beijing, China
(1990 - 1992) Research Fellow, Department of Cytogenetics, National Institute for Family Planning, Beijing, China
(1985 - 1987) Teacher Assistant, Shandong Normal University, Shandong, China
Major Professional Societies
(2006-Present) Member, AAAS
(2002-Present) Member, American Association for Cancer Research
(1998-2001) Member, Japanese Cancer Association
(1997-2001) Member, Japanese Society for Human Genetics
Honors and Awards
(2003-2006) Postdoctoral Training Award, Department of Defense Breast Cancer Research Program
(2004) AACR-Inglenook Vineyards Scholar-in-Training Award, American Association for Cancer Research
(2001) Graduate Student Award, Medical Research Institute, Tokyo Medical and Dental University
(1996-2001) Japanese Government Scholarship Award. The Ministry of Education, Culture, Sports, Science and Technology, Japan. Government of Japan provides scholarships to international students (Tokyo Medical and Dental University recommendation)
Courses taught
CB 7210/PHC 7210: Fundamentals of Cancer Biology
Research Interests
The overall theme of my research is to identify novel genetic alterations associated with cancer initiation and progression, and to elucidate molecular mechanisms and physiological roles of these genes and the proteins they encode. My research program includes three directions: i) The discovery and characterization of novel oncogenes in various tumor types, particularly in breast, prostate, and esophageal cancers; ii) Understanding the fundamental mechanism by which dysregulation of histone-modifying enzymes contributes to tumorigenesis; and iii) Investigation of the roles of endoplasmic reticulum factors in breast cancer malignancy maintenance and therapy resistance. Current studies are centered on histone demethylase GASC1 and endoplasmic reticulum factor ERLIN2 in human breast and prostate cancers. Furthermore, my lab, in collaboration with others, is currently testing novel GASC1 inhibitors both in vitro and in vivo, ultimately working to develop GASC1 inhibitors as new epi-drugs for the treatment of cancer.
Publications
Ion John Campeanu~*, Yuanyuan Jiang~, Lanxin Liu, Maksymilian Pilecki*, Alvina Najor*, Era Cobani*, Morenci Manning*, Xiaohong Mary Zhang, Zeng-Quan Yang. Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer. Scientific Reports. 07/2021. PubMed PMID: PMC8292347/34285249.
Yuanyuan Jiang, Lanxin Liu, Morenci Manning*, Madison Bonahoom*, Aaron Lotvola* , Zhe Yang, Zeng-Quan Yang. Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2'-O-ribose methyltransferase of SARS-CoV-2 coronavirus. JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS. 10/2020. PubMed PMID: PMC7544923/33016237.
Kezhong Zhang, Hui Liu, Zhenfeng Song, Yuanyuan Jiang , Hyunbae Kim, Lobelia Samavati, Hien M Nguyen, Zeng-Quan Yang. The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs. iScience. 08/2020;23(9):101503. PubMed PMID: PMC7490531/32911332.
Yuanyuan Jiang, Xuhui Guo, Lanxin Liu , Shomita Rode, Rui Wang , Hui Liu, Zeng-Quan Yang. Metagenomic characterization of KATs in human cancer and their association with clinic-pathological features. Cancer Science. 05/2020;111(5):1829-1839. PubMed PMID: PMC7226209/32162442.
Morenci Manning~*, Yuanyuan Jiang~, Rui Wang, Lanxin Liu, Shomita Rode, Madison Bonahoom*, Seongho Kim, ZengQuan Yang. Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression. RNA Biology. 04/2020;17(4):474-486. PubMed PMID: PMC7237164/31957540.
Kim H, Williams D, Qiu Y, Song Z, Yang Z, Kimler V, Goldberg A, Zhang R, Yang Z, Chen X, Wang L, Fang D, Lin JD, Zhang K. Regulation of hepatic autophagy by stress-sensing transcription factor CREBH.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 07/01/2019;33(7):7896-7914. PubMed PMID: 30912978.
Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, Sudeshna Bandyopadhyay, Azadeh Stark, Zeng-Quan Yang, Michael P Long, Lawrence I Grossman, Félix Fernández-Madrid. Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis. BMC Cancer. 05/2019;19(1):411. PubMed PMID: PMC6498478/31046734.
Chitra Thakur, Bailing Chen, Lingzhi Li, Qian Zhang, Zeng-Quan Yang, Fei Chen. Loss of Mdig Expression Enhances DNA and Histone Methylation and Metastasis of the Aggressive Breast Cancer. Signal Transduction and Targeted Therapy. 09/2018;3(25). PubMed PMID: PMC6147911/30254753.