Position Title

Professor
Radiation Oncology

Office Location

Gershenson Radiation Oncology Center

Mailing Address

Karmanos Cancer Center
4100 John R Rd. GE00RO
Detroit, MI 48201

Office Phone

313-576-8344

Office Fax

313-576-9625

Education Training

Education
(1980)  Ph.D. Institute of Cancer Research (Royal Postgraduate Medical School), University of London, London, UK
(1980)  M.A. Queens' College, University of Cambridge, Cambridge, UK
(1976)  B.A. Queens' College, University of Cambridge, Cambridge, UK

Postgraduate Training
(1980) Research Scientist, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK 

Professional Experience

Faculty Appointments
(2002-Present) Professor (Tenured), Department of Oncology, Division of Radiation Oncology, Wayne State University School of Medicine, Detroit, MI USA
(1997-2002) Research Scientist, Special appointment grade, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK
(1988-1997) Research Scientist, Tenured appointment, senior grade, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, UK

Hospital or Other Professional Appointments
(2015-Present)  Member, Departmental Promotions and Tenure Committee, Department of Oncology, Wayne State University, Detroit, MI
(2012-Present)  Member, Committee of the Associate Chairs for Research, Wayne State University School of Medicine, Detroit, MI
(2012-Present)  Member, AAPM Working Group on Stereotactic Body Radiotherapy
(2011-Present)  Member, Committee on Bioeffect Modeling and Biologically Equivalent Dose Concepts in Radiation Therapy of the International Commission on Radiation Units and Measurement (ICRU)
(2011-Present)  Member, Radiobiology Practice Exam and Study Guide Subcommittee of the ASTRO Radiation and Cancer Biology Committee
(2008-Present)  Member, Radiation Safety Committee, Division of Radiation Oncology, Department of Oncology, Wayne State University, Detroit, MI
(2005-Present)  Member, Graduate Committee, Wayne State University School of Medicine Medical Physics Graduate Program, Detroit, MI
(2005-Present)  Member, Curriculum & Evaluations Committee, Wayne State University School of Medicine Medical Physics Graduate Program, Detroit, MI
(2005-Present)  Member, Admissions Committee, Wayne State University School of Medicine Medical Physics Graduate Program, Detroit, MI
(2001-Present)  Head of Radiation Biology Program, Department of Oncology, Division of Radiation Oncology, Wayne State University, Detroit, MI
(2000)  Honorary Professor, Department of Oncology, University College, London, UK
(1996)  Honorary Professor Associate, Brunel University, Uxbridge, Middlesex, UK
(1989)  Head of Experimental Oncology, Gray Laboratory Cancer Research Trust, Mount Vernon Hospital, Northwood, Middlesex, UK

Major Professional Societies

AACR: American Association for Cancer Research
ASTRO: American Society for Radiation Oncology
RRS: Radiation Research Society
RSNA: Radiological Society of North America
ESTRO: European Society for Radiotherapy and Oncology
ARR: Association for Radiation Research
University of London Convocation 

Honors and Awards

(2015)  Wayne State University School of Medicine College Teaching Award
(2012)  Marie Curie Prize, World Council of Nuclear Workers, for discovery of Low-Dose Hyper-radiosensitivity
(2004)  Phi Beta Delta Honor Society for International Scholar
(2000)  Honorary Professor, University College London, UK
(1999)  Honorary Member, Royal College of Radiologists, UK
(1996)  Honorary Professor Associate, Brunel University, UK 

Courses taught

CB 7210: Fundamentals of Cancer Biology
CB 7220: Molecular Biology of Cancer Development
CB 7240: Cancer Chemotherapy
CB 7300: Special Topics in Cancer Biology 
ROC 6710: Physics in Medicine
ROC 7060: Applied Radiobiology in Radiological Sciences
ROC 7890: Physics Seminars
RT 4150: Radiobiology of Radiation Oncology

Research Interests

Molecular basis for clinical radiation resistance and diversity seen in the response to radiation therapy, including the study of cancer stem cells;
Development of a complete system of treatment planning based on biologically effective dose to improve our ability to account for variability in biological factors such as radiosensitivity, hypoxia and cell proliferation from patient to patient;
Investigation of soy isoflavones to enhance radiotherapy;
Gene therapy and therapeutic use of stem cells for radioprotection of normal tissues;
Development of high-LET radiotherapy;
Nanoparticles to enhance the radiation effect on radioresistant tumors. 

Publications

1. Joiner MC, Denekamp J, Maughan RL. The use of ‘top-up’ experiments to investigate the effect of very small doses per fraction in mouse skin. Int J Radiat Biol 1986;49:565-80.
2. Marples B, Joiner MC. The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population. Radiat Res 1993;133:41-51.
3. Joiner MC, Mogili N, Marples B, Burmeister J. Significant dose can be lost by extended delivery times in IMRT with x rays but not high-LET radiations. Med Phys 2010;37:2457-65.
4. Hillman GG, Singh-Gupta V, Hoogstra DJ, Abernathy L, Rakowski J, Yunker CK, Rothstein SE, Sarkar FH, Gadgeel S, Konski AA, Lonardo F, Joiner MC. Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma. Radiother Oncol 2013;109:117-25.
5. Seth I, Joiner MC, Tucker JD. Cytogenetic low-dose hyper-radiosensitivity is observed in human peripheral blood lymphocytes. Int J Radiat Oncol Biol Phys 2015;91:82-90.
6. https://pubmed.ncbi.nlm.nih.gov/?term=Michael+Joiner

 

Faculty Status

Rad-Onc

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