Yubin Ge
Position Title
Professor
Basic Science
Office Location
Karmanos Cancer Institute
Elliman Building, RM - 3128
421 E Canfield
Detroit, MI 48201
Mailing Address
Office Phone
313-578-4285Office Fax
313-578-4287Education Training
Education
(1998) PhD, Jilin University, Changchun, China
(1995) MS, Jilin University, Changchun, China
(1992) BS, Jilin University, Changchun, China
Postgraduate Training
(2002-2004) Research Associate, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI
(1999-2002) Postdoctoral Fellow, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI
(1998-1999) Postdoctoral Fellow, Department of Biochemistry, University of Queensland, Brisbane, Australia
Professional Experience
Faculty Appointments
(2024-Present) Professor (Tenure), Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2014-2024) Associate Professor (Tenure), Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2008-2019) Adjunct Professor, College of Life Science, Jilin University, Changchun, China
(2010-2014) Assistant Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2007-2010) Assistant Professor, Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI
(2004-2007) Assistant Professor, Wayne State University School of Medicine, Detroit, MI
Hopsital and Other Professional Appointments
(2004-Present) Member, Barbara Ann Karmanos Cancer Institute, Detroit, MI
Major Professional Societies
Member: American Association for Cancer Research
Active member: American Society of Hematology
Honors and Awards
(2008) Center Director's Quarterly Research Award, Karmanos Cancer Institute
(2007) Faculty Research Excellence Award, Wayne State University School of Medicine
(2004) Chareles J. Epstein Research Award, the National Down Syndrome Society
(2003) Chareles J. Epstein Research Award, the National Down Syndrome Society
(1994) The second prize for The Second China Grand Prix of the Invention of Applied Sciences & Technology for University Students, Beijing, P.R.China
Courses taught
CB 7210: Fundamentals of Cancer Biology
CB 7240: Cancer Chemotherapy
CB 7300 F31: Special Topics in Cancer Biology - Grant Writing
CB 7700: Recent Developments in Cancer Biology
Research Interests
Research in the Ge laboratory spans the basic biology and development of acute leukemia in children, to combinational therapies and translational studies with primary patient specimens. Studies of the Ge laboratory have concerned the biology of critical transcription factors such GATA1, ETS2, and RUNX1 in AML, including identification of high frequency RUNX1-ETO fusion protein isoforms as determinants of chemosensitivity and leukemogenesis and determination of the roles of GATA1 and EST2 in the biology and chemotherapy responses in a specific subtype of AML, acute megakaryocytic leukemia (AMkL) by using clinically relevant cell lines and diagnostic AML blasts. Most recent studies have been focusing on the molecular basis for the remarkable synergism between histone deacetylase (HDAC) inhbitors (HDACIs) and standard chemotherapy drugs used for treating AML, neuroblastoma, and pancreatic cancer.