Position Title

Professor
Basic Science

Office Location

Karmanos Cancer Institute
4100 John R.
Mail Code: HW07AO
Detroit, MI 48201

Office Phone

313-576-8329

Office Fax

313-576-8389

Education Training

Education
(1990)  Post-Doctorate Cancer Immunology/Molecular Biology: Wayne State University, Detroit, MI
(1987)  Ph.D. Physiology: Utah State University, Logan, UT
(1986)  Grad. Minor Applied Statistics and Experimental Designs: Utah State University, UT

Postgraduate Training
(1987-1990) Postdoctoral Research Associate: Cancer Biology and Immunology, Department of Internal Medicine, Division of Hematology and Oncology, Wayne State University, Detroit, MI
(1985-1986)  Research Assistant: Molecular Biology Lab, Department of Biometeorology, Utah State University, UT
(1985-1986)  Graduate Teaching Assistant: Stress Physiology, Utah State University, UT
(1983-1985)  Graduate Teaching Assistant: Tissue Culture, Utah State University, UT

Professional Experience

Faculty Appointments
(2005-Present)  Professor of Medicine (Tenure), Research Educator Track, Cancer Biology and Immunology, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan
(1996-Present)  Member, Cancer Biology Graduate Program Wayne State University School of Medicine, Detroit, MI
(1991-Present)  Associate Faculty Member, Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan
(1995-2000)  Member, University Animal Investigation Committee, Wayne State University, Detroit, Michigan
(1998-2005)  Associate Professor of Medicine (Tenure), Research Educator Track, Cancer Biology and Immunology, Department of Internal Medicine, Division of Hematology and Oncology, Wayne State University School of Medicine, Detroit, Michigan
(1991-1997)  Assistant Professor of Medicine, Research Educator Track, Cancer Biology and Immunology, Department of Internal Medicine, Division of Hematology and Oncology, Wayne State University School of Medicine, Detroit, Michigan

Hospital or Other Professional Appointments
(2008-Present) Director, GI-Cancer Research, Karmanos Cancer Institute, Detroit, Michigan
(1995-Present) Member, Karmanos Cancer Institute, Detroit, MI

Major Professional Societies

(2000-Present)  American Pancreatic Association (APA)
(1991-Present) American Association for Cancer Research (AACR)
(1992-Present) American Society of Hematology (ASH)
(1991-Present) International Society for Experimental Hematology (ISEH)
(1994-2005)  The Detroit Immunological Society (DIS)
(1995-1996)  The Leukocyte Society
(1982-1988)  Sigma XI
(1992-1996)  American Association for the Advancement of Science (AAAS)
(1985-2014) American UTAH Science (US)
(1988-1995)  American Tissue Culture Association (TCA)

Honors and Awards

(2007-Present) Member, Editorial Board, Recent Patents of Anti-Cancer Drug Discovery
(2012) Member, Editorial Board of the journal Scientifica
(2012) Advisory board member, Embrace the Day Foundation
(2011) Delegate, representing the president of Utah State University, Presidential Inauguration
(2011) Karmanos cancer center director award for outstanding basic and translational published research from KCI (for Oncogene paper)
(2011) Member, Editorial Board of World Journal of Gastrointestinal Pathophysiology (WJGP)
(2011) Member, Editorial Board of Journal of Blood & Lymph
(2010) Faculty Mentor Award, Office of the Vice President for Research, Wayne State University
(2010) Recognition Letter from Vice President for Research, for a new award RO1 and R21 project with University of Michigan, WSU
(2010) Certification of Completion. 5th annual state of the art treatment of GI cancer conference
(2009) Leukemia Society of America Award
(2008) Thank you letter from the Chairman of Department of Immunology and Microbiology for teaching Year II medical students the course of Year II Medical Microbiology, Immunology and Infectious Diseases
(2007) Thank you letter from WSU president for $14,980 donation to support School of Medicine
(2005) Teaching Award, School of Medicine, Wayne State University
(2004) A new invention in cancer research: HoxB4 gene as therapeutic agent
(2002, 2003, 2004, 2006) Inventor Recognition Event by Wayne State University
(2001) Science & Engineering Fair of Metro Detroit (SEFMD), Judge for Biology and Health
(2001) College Teaching Award, School of Medicine, Wayne State University(2000) President's Award for Basic Research, Karmanos Cancer Institute
(2000) International Science and Engineering Fair. Grand Awards Judge for Medicine and Health
(1999-2001) R01-grant, U.S. Public Health Service, NIH, NCI
(1999) Selected as a reviewer for the Rapid Access to Intervention Development RAID NCI-program
(1998,1999, 2000) Serving as a Judge for the Cancer Biology Graduate Research Day, Wayne State University/Karmanos Cancer Institute
(1996-2000) Leukemia Society of America Award
(1998) WZNK Radio Recognition Award, (KARMANOS Cancer Institute serving Detroit communities)
(1998) Wayne State University-School of Medicine College Teaching Award(1997) Who's Who in the World
(1995) Vice President Research Award, Wayne State University
(1994) Pan Pacific Lymphoma Recognition Award, Omaha, Nebraska
(1994) First Award Winner, Research Poster, The Detroit Immunological Society
(1994) Television Recognition Award (Channels 2&7): Phase I Clinical Evaluation of
(1994) Bryostatin 1 in Replaced Lymphoma and CLL
(1988) Sigma XI, Scientific Research Society
(1987) Outstanding Scholastic Achievement, President, Utah State University
(1987) Certification of Achievement in the Development at local level, Utah State Univ
(1985) Award, Institute of international Education, USA
(1982-1984)  First Class Scholarship, Mosul University, Mosul, Iraq

Courses taught

CB 7710: Independent Studies in Cancer Biology
CB 7996: Research in Cancer Biology

Research Interests

The primary focus of Dr. Mohammad’s research is the design, development and pre-clinical testing of novel small molecule drugs for the treatment of cancer. Being the Director of GI research he foresees the testing of new drugs in pancreatic and colon tumor models. In the past a number of agents have come from his lab to the clinic namely dolastatin, Aurastatin, Bcl-2 inhibitor AT-101, MDM2 inhibitor and very recently the nuclear export protein CRM1 inhibitors KPTs. He has active NIH funding on Bcl-2 inhibitor (AT-101); Mcl-1 inhibitor (UMI-77); and KPTs.  KPT drugs happen to be among the fastest agents to come to the clinic and are being tested in colon and very soon in pancreatic patients. He specializes in animal tumor model studies and has collaborated extensively with many basic, translational and pharmaceutical researchers to test novel agents in his advanced animal systems.

Publications

Selected from more than 195 peer-reviewed papers and book chapters:

1. Mohammad RM, Dugan MC, Mohamed AN, Almatchy VP, Flake TM, Dergham ST, Shields AF, Al-Katib AA, Vaitkevicius VK. Establishment of a human pancreatic tumor xenograft model: potential application for preclinical evaluation of novel therapeutic agents. Pancreas. 1998 Jan;16(1):19-25. PMID 9436858

2. Zhang Y, Dawson MI, Ning Y, Polin L, Parchment RE, Corbett T, Mohamed AM, Feng K-C, Farhana , Rishi AK, Hogge D, Leid M, Peterson VJ, Zhang X-K, Mohammad RM, Lu J-S, Willman C, VanBuren E , Biggar S, Edelstein M, Eilender D, Fontana JA. Induction of Apoptosis in Retinoid Refractory AML by a Novel AHPN Analog. BLOOD, 102:3743-3752, 2003.

3. Azmi AS, Philip PA, Beck FW, Wang Z, Banerjee S, Wang S, Yang D, Mohammad RM. MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene.6;30(1):117-26, 2011.

4. Azmi AS, Aboukameel A, Bao B, , Philip PA, Kauffman M, Shacham S, Mohammad RM. Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice. Gastroenterology. 2012 Oct 23:S0016-5085(12)01552-1. PMID: 23089203.

5. Azmi AS, Aboukameel A, Bao B, Philip PA, Kauffman M, Shacham S, Mohammad RM. Selective inhibitors of nuclear export block pancreatic cancer cell proliferation and reduce tumor growth in mice. Gastroenterology. 2013 Feb;144(2):447-56. 23089203

6. Gao J, Azmi AS, Aboukameel A, Kauffman M, Shacham S, Abou-Samra AB, Mohammad RM. Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer. Oncotarget. 2014 Jun 15;5(11):3444-54. 24899509

7. Azmi AS, Muqbil I, Wu J, Aboukameel A, Senapedis W, Baloglu E, Bollig-Fischer A, Dyson G, Kauffman M, Landesman Y, Shacham S, Philip PA, Mohammad RM. Targeting the Nuclear Export Protein XPO1/CRM1 Reverses Epithelial to Mesenchymal Transition. Sci Rep. 2015 Nov 5;5:16077. doi: 10.1038/srep16077.

8. Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta

 

https://pubmed.ncbi.nlm.nih.gov/?term=Ramzi+mohammad

 

Faculty Status

Basic Science

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