Position Title
Associate Professor - Research
Basic Science
Office Location
Karmanos Cancer Institute
Elliman Building, RM - 1222
421 E Canfield
Detroit, MI 48201
Mailing Address
Karmanos Cancer Institute
4100 John R., EL01AM
Detroit, MI 48201
Office Phone
313-578-4270
Office Fax
313-831-7518
Education Training
Education
(1997) Ph.D., Biochemistry, Wayne State University School of Medicine, Detroit, MI, Major Professor: Dr. Samuel C. Brooks
(1982) B.S., Microbiology, Michigan State University, East Lansing, MI
Postgraduate Training
(1998-2002) Research Associate, Department of Internal Medicine, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, MI (PI: Thomas Corbett, PhD)
Professional Experience
Faculty Appointments
(2012-Present) Associate Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2010-2012) Assistant Professor, Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(2002-2010) Assistant Professor, Department of Internal Medicine, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, MI
Hospital or Other Professional Appointments
(2013-Present) Director, Animal Model and Therapeutic Evaluation Core (AMTEC), developing core, Karmanos Cancer Institute, Detroit, MI
(2010-Present) Director, KCI Cell Resource Distribution Core, Karmanos Cancer Institute, Detroit, MI
(2009-Present) Chair, WSU Institional Animal Care and Use Committee (IACUC), Wayne State University, Detroit, MI
(2006-Present) Member, WSU Institional Animal Care and Use Committee (IACUC), Wayne State University, Detroit, MI
Major Professional Societies
American Association for Cancer Research
Honors and Awards
(1994) Recipient of Heberlein Fellowship, Wayne State University, Detroit, MI
Courses taught
CB 7990: Advanced Topics in Cancer Biology
Research
Animal tumor models
Cancer cell lines
Anticancer drug discovery
Therapy and preclinical development
Drug resistant/Sensitive cell lines
Publications
Selected from 56 publications:
1: Cherian C, Kugel Desmoulin S, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Gangjee A, Matherly LH. Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter. Cancer Chemother Pharmacol 2013 Feb 15. [Epub ahead of print] PMID: 23412628.
2. Desmoulin SK, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH. Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Mol Pharmacol 2012 Oct; 82(4):591-600. Epub 2012 Jun 26. PubMed PMID: 22740639; PubMed Central PMCID: PMC3463226.
3. Ahmed Neesar, Minghui Zeng, Lisa Polin, Chozhavendan Rathinam, Wei-Zen Wei, Richard Flavell, Ramin Massoumi and K Venuprasad. The E3 ligase Itch and deubiquitinase Cyld co-operatively regulate Tak1 and inflammation. Nat Immunol. 2011 Nov 6;12(12):1176-83. doi: 10.1038/ni.2157. PubMed PMID: 22057290; PubMed Central PMCID: PMC3219826.
4. Risinger AL, Jackson EM, Polin LA, Helms GL, LeBoeuf DA, Joe PA, Hopper-Borge E, Luduea RF, Kruh GD, Mooberry SL. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res.2008 Nov 1;68(21):8881-8. doi: 10.1158/0008-5472.CAN-08-2037. PubMed PMID:18974132; PubMed Central PMCID: PMC2727482.
5. Kessel D, Reiners JJ Jr, Hazeldine ST, Polin L, Horwitz JP. The role of autophagy in the death of L1210 leukemia cells initiated by the new antitumor agents, XK469 and SH80, Mol Cancer Ther 2007 Jan;6(1):370-9. PubMed PMID:17237296; PubMed Central PMCID: PMC2877038.
6. Hazeldine ST, Polin L, Kushner J, White K, Corbett TH, Horwitz JP. Part 5: Synthesis and biological evaluation of conformationally constrained analogs of the antitumor agents XK469 and SH80. Bioorg Med Chem, 14(7):2462-7, 2006 Apr 1; [epub 2005 Dec 05]. PMID: 16337128
7. Evelhoch JL, LoRusso PM, He Z, DelProposto Z, Polin L, Corbett TH, Langmuir P, Wheeler C, Stone A, Leadbetter J, Ryan AJ, Blakey DC, Waterton JC. Magnetic resonance imaging measurements of the response of murine and human tumors to the vascular-targeting agent ZD6126. Clin Cancer Res. 2004 Jun 1;10(11):3650-7.PMID: 15173071.
8. Polin L, White K, Kushner J, Paluch J, Simpson C, Pugh S, Edelstein MK, Hazeldine S, Fontana J, LoRusso P, Horwitz JP, Corbett TH. Preclinical efficacy evaluations of XK-469: dose schedule, route and cross-resistance behavior in tumor bearing mice. Invest New Drugs. 2002 Feb; 20(1):13-22. PMID: 12003190.
Faculty Status
Basic Science
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