Position Title

Professor

Office Location

Mid-Med Lofts, Suite 3000
87 E Canfield
Detroit, MI 48201

Mailing Address

Office Phone

313-576-8652

Education Training

Education
(1972-1976) Ph.D. Biostatistics, University of Michigan, Ann Arbor, MI
(1972-1974) M.P.H. Biostatistics, University of Michigan, Ann Arbor, MI
(1969-1971) M.A. Mathematical Statistics, Wayne State University, Detroit, MI
(1965-1969) B.S. Mathematics, Wayne State University, Detroit, MI

Professional Experience

Faculty Appointments
(2010-Present) Tenured Professor of Oncology, Department of Oncology, Wayne State University School of Medicine, Detroit, MI
(1999-Present) Biostatistics Core Assistant Director, Department of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI
(2008-2010) Tenured Professor of Medicine, Division of Hematology and Oncology, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI
(1997-2010) Professor of Oncology, Karmanos Cancer Institute, Detroit, MI
(1993-2007) Professor of Medicine, Division of Hematology and Oncology, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI
(1989-1999) Biostatistics Core Leader, Karmanos Cancer Institute, Detroit, MI
(1986-1989) Director of Biostatistics, Division of Hematology and Oncology, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI.
(1986-1993) Associate Professor of Medicine, Division of Hematology and Oncology, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI
(1979-1986) Biostatistician, Japan‑Hawaii Cancer Study, Kuakini Medical Center, Honolulu, HI
(1976-1979) Assistant Biometrician, and:
(1978-1979) Assistant Professor of Biometrics, Department of Biomathematics and Southwest Oncology Group Biostatistical Office, MD Anderson Hospital and Tumor Institute, University of Texas System Cancer Center, Texas Medical Center, Houston, TX
(1970-1972) Research Assistant (Programmer/Statistician): Division of Oncology, Wayne State University, School of Medicine, Detroit, MI

Hospital or Other Professional Appointments
(1992-Present) Full Member, Karmanos Cancer Institute, Detroit, MI
(1987-1998) Associate Staff Member, Harper Hospital, Detroit, MI
(1986-1997) Adjunct Scientist, Division of Epidemiology, Karmanos Cancer Institute, Detroit, MI
(1974) Programmer/Statistician (part‑time): Radiation Therapy Center University of Michigan Hospital, Ann Arbor, MI
(1973) Statistician, Department of Biomathematics, MD Anderson Hospital and Tumor Institute, Texas Medical Center, Houston, TX

Major Professional Societies

(1987-Present) American Statistical Association, Detroit Chapter
(1973-Present) International Biometrics Society
(1973-Present) American Statistical Association
(1987-2007) American College of Epidemiology
(1980-1997) Society for Epidemiologic Research
(1980-1986) American Statistical Association, Hawaii Chapter
(1977-1980) American Society of Clinical Oncology
(1977-1980) American Association for Cancer Research, Southwest Section

Honors and Awards

(2015) School of Medicine College Teaching Award, Department of Oncology, Wayne State University, Detroit, MI
(2012) School of Medicine College Teaching Award, Department of Oncology, Wayne State University, Detroit, MI
(2008) Teaching Excellence Award, Fellowship Training Program, Division of Hematology & Oncology, Wayne State University, Detroit, MI
(2006) School of Medicine College Teaching Award, Department of Oncology, Wayne State University, Detroit, MI
(2002) Detroit Chapter, American Statistical Association, 2002 Chapter Service Recognition Award, conferred 8/02 at the Joint Statistical Meetings conference
(2002) Best Teacher Award, Fellowship Training Program, Division of Hematology & Oncology, Wayne State University, Detroit, MI
(2000) Best Teacher Award, Fellowship Training Program, Division of Hematology & Oncology, Wayne State University, Detroit, MI
(1999) School of Medicine College Teaching Award, Wayne State University, Detroit, MI
(1975-1976) University of Michigan Cancer Research Institute Fellow
(1974-1975) University of Michigan Rackham Graduate School Fellow
(1972-1974) US Public Health Service Special Purpose Trainee
(1970-1971) Wayne State University Graduate Professional Scholar
(1970‑1971) Wayne State University Department of Mathematics Honor Roll
(1970‑1971) Wayne State University Department of Mathematics Honor Roll

Research

Statistical methods in clinical trials design and analysis;  statistical methods in epidemiology;  survival data analysis;  prostate cancer;  kidney cancer;  Phase 1 trials;  Phase 2 trials;  cryotherapy studies;  the National Center for Vermiculite and Asbestos-related Cancers (NCVAC).

Publications

Most recent 10, from a total of 192 in peer-review journals

 

 192.  BalanV,  WangY,  Nangia-MakkerP,  KhoD,  Bajaj M, SmithD,  HeilbrunL,  RazA, HeathE. Galectin-3:  a possible complementary marker to the PSA blood test.

Oncotarget, 4(4):542-549, 2013.PMID:  23625538

(My role:  study design, statistical analysis and report writing, and manuscript writing.)

191.  Bang HJ*, Littrup PJ,  Currier BP*,  Goodrich DJ*,  Choi M,  Heilbrun LK,  Goodman AC.

Percutaneous cryoablation of metastatic lesions from colorectal cancer:  Efficacy and

feasibility with survival and cost-effectiveness observations.    

ISRN Minimally Invasive Surgery, Volume 2012, Article ID 942364, 10 pages, 2012.

(My role:  study design, statistical analysis and report.)

 

190.  Almhanna K,  El-RayesB,  SethiS*,  DysonG,  HeilbrunL,  PhilipPA,  Sarkar F.

         Association between COX-2 expression and effectiveness of COX-2 inhibitors in phase II

         trial in patients with metastatic colorectal adenocarcinoma.     Anticancer Research, 

         32(8):3559-3563, 2012.       PMID:  22843946

         (My role:  study design, data collection, and manuscript writing.)

 

189.  OgitaS*,  TejwaniS*,  HeilbrunL,  Fontana J,  HeathEI,  FreemanS,  SmithD,

         BaranowskiK,  VaishampayanU.     Pilot phase II trial of bevacizumab monotherapy in

         nonmetastatic castrate-resistant prostate cancer.     ISRN Oncology, Article ID 242850,

       2012.        PMCID:   PMC3382396

         (My role:  study design, statistical analysis and report writing, and manuscript writing.)

 

188.  Bang HJ*,  Littrup PJ,  GoodrichDJ*,  Currier BP*,  Aoun HD,  Heilbrun LK,

         Vaishampayan U,  Adam B,  Goodman AC.     Percutaneous cryoablation of metastatic

         renal cell carcinoma for local tumor control:   Feasibility, outcomes, and estimated cost-

         effectiveness for palliation.     Journal of Vascular and Interventional Radiology,

         23(6):770-777, 2012.     PMID:  22538119

         (My role:  statistical analysis and report writing, and manuscript writing.)

 

187.  Bang HJ*,  Littrup PJ,  Currier BP*,  GoodrichDJ*,  Aoun HD,  Klein LC*,  Kuo JC*, 

         Heilbrun LK,  Gadgeel S,  Goodman AC.     Percutaneous cryoablation of metastatic

         lesions from non-small cell lung carcinoma:   Initial survival, local control, and cost

         observations.     Journal of Vascular and Interventional Radiology, 23(6):761-769, 2012.

         PMID:  22626267

         (My role:  statistical analysis and report writing, and manuscript writing.)

 

186.  Kafri Z,  Heilbrun L,  Sukari A,  Yoo G,  Jacobs JR,  Lin H-S,  Mulrenan H,  Smith D,

         Kucuk O.     Phase II study of gemcitabine and docetaxel combination (GEMDOC) in

         patients with previously treated recurrent or metastatic squamous cell carcinoma of the

         head and neck.     ISRN Oncology, Volume 2012, Article ID 159568, 6 pages, 2012.

         (My role:  study design, statistical analysis and report writing, and manuscript writing.)

         PMCID:   PMC3359684

 

185.  Kong D,  Heath E,  Chen W,  Cher M,  Powell I,  Heilbrun L,  Li Y,  Ali S,  Sethi S*,

         Hassan O,  Huang C,  Gupta N,  Chitali D,  Sakr WA,  Menon M,  Sarkar FH.

         Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer

         stem cell signatures that are attenuated by BR-DIM.     PLoS One, 7(3):e33729, 2012.

       (My role:  study design, statistical analysis, and manuscript writing.)        PMC3307758

 

184.  Kong D,  Heath E,  Chen W,  Cher M,  Powell I,  Heilbrun L,  Li Y,  Ali S,  Sethi S*,

         Hassan O,  Huang C,  Gupta N,  Chitale D,  Sakr WA,  Menon M,  Sarkar FH.

         Epigenetic silencing of miR-34a in human prostate cancer cells and tumor tissue specimens

         can be reversed by BR-DIM treatment.        PMCID: PMC3275434

       American Journal of Translational Research, 4(1):14-23, 2012.    

         (My role:  study design, statistical analysis, and manuscript writing.)

 

183.  Naing A,  Kurzrock R,  Burger A,  Gupta S,  Lei X,  Busaidy N,  Hong  D,  Chen HX,

         Doyle LA,  Heilbrun LK,  Rohren E,  Ng C,  Chandhasin C,  LoRusso P.     Phase I trial of

         cixutumumab combined with temsirolimus in patients with advanced cancer.

         Clinical Cancer Research, 17(18):6052-6060, 2011.

         (My role:  study design, statistical analysis and report writing, and manuscript writing.)

 

PubMed Database Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=lance+heilbrun

Faculty Status

Population Science

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