Avraham Raz

raza@karmanos.org

Avraham Raz

Position Title

Professor of Oncology and Pathology
Basic Science

Office Location

Karmanos Cancer Institute
Elliman Building, RM - 1130
421 E Canfield
Detroit, MI 48201

Mailing Address

Karmanos Cancer Institute

4100 John R., EL01ME

Detroit, MI 48201

Office Phone

313-578-4330

Office Fax

313-831-7518

Education Training

Education
(1978) Ph.D., The Weizmann Institute of Science, Rehovot, Israel
(1972) M.Sc. (with distinction) Physiology, The Ben-Gurion University of the Negev, and the Hebrew University of Jerusalem, Israel
(1970) B.Sc. Biology, The Ben-Gurion University of the Negev, Beer-Sheva, Israel

Postgraduate Training
(1980-1981) Research Fellow, Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
(1978-1981) Visiting Scientist, National Cancer Institutes, Frederick Cancer Research Facility, Frederick, MD

Professional Experience

Faculty Appointments
(1997-Present) Professor, Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, Michigan
(1992-Present) Professor, Department of Pathology, Wayne State University, School of Medicine, Detroit, Michigan
(1992-Present) Professor, Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, Michigan
(1989-Present) Faculty, Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, Michigan
(1995) Tenured Granted
(1988-1992) Adjunct Professor, Department of Radiation Oncology, Wayne State University School of Medicine, Detroit, Michigan
(1986-1988) Associate Professor, Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
(1981-1986) Senior Scientist, the Department of Cell Biology, The Weizmann Institute of Science, Rehovot, Israel

Hospital or Other Professional Appointments
(1990-Present) Director, Tumor Progression and Metastasis, Barbara Ann Karmanos Cancer Institute, (Michigan Cancer Foundation) Meyer L. Prentis Comprehensive Cancer Center of Metropolitan Detroit, Michigan
(1987-Present) Member, Barbara Ann Karmanos Cancer Institute (Michigan Cancer Foundation), Detroit, Michigan
(1995-2000) Director, Division of Basic Research, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
(1987-1990) Director of Cancer Metastasis Program, Barbara Ann Karmanos Cancer Institute (Michigan Cancer Foundation), Detroit, Michigan
Editor-in-Chief Cancer Metastasis Reviews

Major Professional Societies

American Association for Cancer Research
American Society for Cell Biology
American Association for the Advancement of Science
European Association for Cancer Research
Metastasis Research Society
Southwest Oncology Group

Honors and Awards

(2015) Plenary spleaker and session chair EMBO workshop on Cell Biology of Animal Lectins, Rehovot, Israel
(2015) Plenary Speaker The 7th International Conference on Tumor Microenvironment: Prograssion, Therapy, & Prevention, Tel-Aviv, Israel
(2013) "Faculty Award for Career Achievement", Karmanos Cancer Institute, Detroit, MI
(2013) Visiting Professor, Northeast Normal University, Changchun, China
(2013) "Kales Award in Oncology", Karmanos Cancer Institute, Detroit, MI
(2013) "Outstanding Research Achievement Award", Wayne State University School of Medicine, Detroit, MI
(2012) Cold Spring Harbor Asia / International Cancer Microenvironment Society Joint Conference on Tumor Microenvironment Organizing Committee and Plenary Lecture Suzhou, China
(2012) Chair- The 8th Annual Midwest Carbohydrate Research Symposium, WSU, Detroit
(2012) Reuben Lotan Distinguished Lecture- University of Texas , MD Anderson Cancer Center
(2011) Keynote Speaker, 26h Annual Research Meeting of the Japanese Orthopaedic Association, Gunma, Japan
(2007) Plenary Lecturer- Japan's 59th Broncho-Esophagological Society
(2007) MERIT Award, Division of Cancer Biology, National Institute of Health, National Cancer Institute, The Role of Tumor Cell Surface Lectins in Metastasis, R37CA046120-19 Featured Synopsis in Profiles and Legacies, Cancer Biology and Therapies, Sugar Recognition and Metastasis, From the Birth of a Research Field to the Clinic, Landes Bioscience
(2005) Paget-Ewing Award International Metastasis Research Society
(2004) Plenary Lecturer- Japan's Urological Society
(2003) Plenary Lecturer- British Cancer Research Meeting, United Kingdom
(2001) Plenary Lecturer- The Japanese Metastasis Society, Japan
(2001) Visiting Professor - University of Pennsylvania Medical Center
(2000) R.E. Bob Smith Lecture Award - UTMD Anderson Cancer Center
(2000-2002) President, International Metastasis Research Society
(1998-2000) President Elect, International Metastasis Research Society
(1998-2000) Invited member of the Michigan State Legislative Committee
(1995) International Journal of Oncology - Featured Cover Story
(1994) The Maximilian-Nitze Award - The German Urological Society
(1992) Board of Directors - The International Metastasis Society
(1987) Endowed Chair - The Paul Zuckerman Support Foundation for Cancer Research. Michigan Cancer Foundation
(1987-1988) Leo & Julia Forchheimer Center for Molecular Genetics, The Weizmann Institute of Science
(1985) "H. Dudley Wright Research Award" in Membrane Research. The Weizmann Institute of Science
(1983) Incumbent of the Sophie M.T. & Richard S. Richards Career Development Chair in Cancer Research in perpetuity. Endowed by Mrs. Sophie M.T. Richards
(1976) "Bondi Memorial Award" for graduate students of the Feinberg Graduate School of the Weizmann Institute of Science

Research Interests

Dr. Raz's goal is to further the understanding of tumor biology, cancer progression and metastasis using in vitro and in vivo methodologies.

Publications

Harazono Y, Kho DH, Balan V, Nakajima K, Hogan V, Raz A. (2015) Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling. Oncotarget.

Wolfenden M, Cousin J, Nangia-Makker P, Raz A, Cloninger M (2015) Glycodendrimers and Modified ELISAs: Tools to Elucidate Multivalent Interactions of Galectins 1 and 3. Molecules. 20(4):7059-96. doi: 10.3390/molecules20047059. PMID: 25903363.

Zhang T, Kho DH, Wang Y, Harazono Y, Nakajima K, Xie Y, Raz A. (2015) Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer. PLoS One. 2015 Mar 19;10(3):e0118448. doi: 10.1371/journal.pone.0118448. eCollection. PMID: 25789613.

Harazono Y, Kho DH, Balan V, Nakajima K, Zhang T, Hogan V, Raz A. (2015) Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells. Oncotarget. ;5(20):9992-10001. PMID: 25393982.

Menachem A, Bodner O, Pastor J, Raz A, and Kloog Y. (2015) Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors Cell Death Discovery (NPG, In Press).

Xu, J., Zhou, JY, Xu Z, Kho DH, Zhuang Z, Raz A, Wu GS. (2014) The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling. Cell Cycle.13:3750-8. PMID: 25551360.

Goodman CK, Wolfenden ML, Nangia-Makker P, Michel AK, Raz A, Cloninger MJ.(2014) Multivalent scaffolds induce galectin-3 aggregation into nanoparticles. Beilstein J Org Chem. 10:1570-7. PMID: 25161713.

Michel AK, Nangia-Makker P, Raz A, Cloninger MJ. (2014) Lactose-functionalized dendrimers arbitrate the interaction of galectin-3/MUC1 mediated cancer cellular aggregation. Chembiochem.15:2106-12. PMID: 25138772.

Gao X, Balan, V, Tai, G, Raz, A. (2014) Galectin-3 induces cell migration via a calcium-sensitive MAPK/ERK1/2 pathway. Oncotarget. Apr 30; 5(8):2077-84. PMID: 24809457.

Harazono Y, Kho D-H, Balan V, Nakajima K, Zhang T, Hogan V, Raz A. (2014) Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells Oncotarget. Oct 30; 5:9992-10001.

PubMed Database Link: https://pubmed.ncbi.nlm.nih.gov/?term=Avraham+Raz

Faculty Status

Basic Science

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